mai exact spune: "gen or cell therapy..."
si mai pe inteles, in engleza insa. de aici preluat
https://www.esgct.eu...ll-therapy.aspx
What is gene and cell therapy?
Gene and cell therapy is the use of genes and cells to treat disease. A gene is the unit of DNA that contains hereditary information that is passed down from generation to generation. All genes together are called the genome. Genes may contain information about visible traits, such as height or eye colour. Many genes contain the instructions for RNA or protein molecules that are not visible from the outside, but perform important functions in the body's cells. Cells are the building blocks of plants and animals (including humans). They are small functional units that work together to form organs and tissues.
Genetic diseases are caused by errors, or mutations, in genes that result in a loss or change of function of RNA or protein molecules. These mutations can be passed down from parents to children or can happen spontaneously. Humans have two copies of each gene, one inherited from their mother and one inherited from their father. Dominant mutations cause disease when only one of the copies has the mutation, while recessive mutations only cause disease if both copies are affected by the mutation. As long as an individual has one healthy copy (scientists call this wild type) of a recessive gene, they will be healthy. We call these individuals carriers. This explains why in some families some children (those with two copies of the mutation) are ill, while others (those with one wild type and one mutated copy) are healthy carriers.
Genetic diseases are caused by errors, or mutations, in genes that result in a loss or change of function of RNA or protein molecules. These mutations can be passed down from parents to children or can happen spontaneously. Humans have two copies of each gene, one inherited from their mother and one inherited from their father. Dominant mutations cause disease when only one of the copies has the mutation, while recessive mutations only cause disease if both copies are affected by the mutation. As long as an individual has one healthy copy (scientists call this wild type) of a recessive gene, they will be healthy. We call these individuals carriers. This explains why in some families some children (those with two copies of the mutation) are ill, while others (those with one wild type and one mutated copy) are healthy carriers.
Gene therapy is the use of genetic material to treat genetic diseases. This may involve adding a wild type copy of the gene (gene addition) or altering a gene with mutation to the wild type gene (gene editing). The treatment may take place outside of the body (ex vivo) or inside the body (in vivo). To get the gene into the genome inside the cells, modified viruses or other vectors are used.
Cell therapy is the use of cells that are taken either from the patient themselves or a donor to treat diseases. Cells used for cell therapy are often stem cells, cells that can mature into different types of specialised cells. Cells used for cell therapy may or may not be genetically altered. It is sometimes easier to remove cells from the body, treat them with gene therapy and then place them back than treating the cells inside the body. This is the case for gene therapy for blood disorders. Gene and cell therapy therefore often go together, which is reflected in the name of our society.
For more information on stem cells, please see the EuroStemCell website. Further informative videos about gene therapy include those by gene therapy companies AGCT and bluebird bio.
Cell therapy is the use of cells that are taken either from the patient themselves or a donor to treat diseases. Cells used for cell therapy are often stem cells, cells that can mature into different types of specialised cells. Cells used for cell therapy may or may not be genetically altered. It is sometimes easier to remove cells from the body, treat them with gene therapy and then place them back than treating the cells inside the body. This is the case for gene therapy for blood disorders. Gene and cell therapy therefore often go together, which is reflected in the name of our society.
For more information on stem cells, please see the EuroStemCell website. Further informative videos about gene therapy include those by gene therapy companies AGCT and bluebird bio.
Editat de cristina30, 30 noiembrie 2021 - 13:48 .
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